Texas 3-Step decellularization protocol: Looking at the cardiac extracellular matrix

Isolating Extracellular Matrix by Liver Decellularization

INTRODUCTION Liver Fibrosis is the 12th most leading cause of the death in the United States and 45% of all deaths in the developing world are caused by a fibrotic disease. [1] With the increase rate in fibrotic disease, there is an increased need for transplants which is exceeding the number of donors available. Fibrosis in the liver remains silent until it reaches the stage of liver failure, ...

Texas at Austin 3

Interfering the Aldosterone-Cardiac Extracellular Matrix Relationship

Cardiac extracellular matrix undergoes extensive and continuous turnover involved in the lesion-reparation process, such as in cardiac remodeling, in hypertensive cardiac hypertrophy, in dilated cardiomyopathy, after myocardial infarction in the transition to heart failure, and during the progression of left ventricular dysfunction. Cardiac fibrosis is a major determinant of diastolic dysfuncti...

Molecular imaging of the cardiac extracellular matrix.

In almost all cardiac diseases, an increase in extracellular matrix (ECM) deposition or fibrosis occurs, mostly consisting of collagen I. Whereas replacement fibrosis follows cardiomyocyte loss in myocardial infarction, reactive fibrosis is triggered by myocardial stress or inflammatory mediators and often results in ventricular stiffening, functional deterioration, and development of heart fai...

Reinforcement of a decellularized extracellular matrix-derived hydrogel using nanofibers for cardiac tissue engineering

The role of heart disease in increasing worldwide death and the limited availability of organs for transplantation have encouraged multiple strategies to fabricate functional and implantable constructs. One of these strategies is to develop a biologically similar heart tissue scaffold, in which two types of fiber and hydrogel are commonly used. Toward this goal, taking advantage of both hydroge...